Which signal in the gut is anorexigenic and originates in the duodenum?

Which signal in the gut is anorexigenic and originates in the duodenum?

• A. Leptin
• B. CCK
• C. GLP-1
• D. Ghrelin

Answer: (B)

Cholecystokinin, released by I cells in the duodenum in response to fats and proteins, acts as an anorexigenic signal. It communicates with the brain via vagal afferents and helps reduce hunger while also slowing gastric emptying to promote a sense of fullness after a meal. Leptin comes from fat tissue and signals long-term energy stores, not the duodenum. GLP-1 is released mainly from L-cells in the distal small intestine and colon and also reduces appetite, but its primary origin isn’t the duodenum. Ghrelin is produced in the stomach and stimulates hunger. So the duodenal anorexigenic signal is cholecystokinin.

Cholecystokinin, released by I cells in the duodenum in response to fats and proteins, acts as an anorexigenic signal. It communicates with the brain via vagal afferents and helps reduce hunger while also slowing gastric emptying to promote a sense of fullness after a meal. Leptin comes from fat tissue and signals long-term energy stores, not the duodenum. GLP-1 is released mainly from L-cells in the distal small intestine and colon and also reduces appetite, but its primary origin isn’t the duodenum. Ghrelin is produced in the stomach and stimulates hunger. So the duodenal anorexigenic signal is cholecystokinin.